What is Telmisartan & Amlodipine Tablets ?
Telmisartan & Amlodipine Tablets are a combination medication that contains two active ingredients: telmisartan and amlodipine. This combination is used to treat high blood pressure (hypertension). Telmisartan is an angiotensin II receptor blocker (ARB), and amlodipine is a calcium channel blocker. By combining these two types of drugs, the medication can address high blood pressure from different angles, providing an enhanced therapeutic effect.
Telmisartan & Amlodipine Tablets Use
- Enhanced Blood Pressure Control: Combining these two medications can often lead to better control of blood pressure compared to using one medication alone.
- Reduced Side Effects: Using lower doses of each medication in combination may result in fewer side effects compared to using higher doses of a single medication.
- Convenience: Taking a single tablet that contains both medications can be more convenient for patients compared to taking multiple tablets.
- Synergistic Effects: The different mechanisms of action of Telmisartan and Amlodipine mean that they can complement each other, potentially providing a more comprehensive approach to blood pressure control.
- Protection of Target Organs: These medications not only lower blood pressure but also have additional benefits in protecting organs like the heart and kidneys from the damaging effects of high blood pressure.
Telmisartan & Amlodipine Tablets – Mechanism of Action and Pharmacology
- Telmisartan (ARB):
- Telmisartan works by blocking the effects of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. By blocking these effects, telmisartan causes blood vessels to relax and widen, reducing peripheral resistance and lowering blood pressure.
- Amlodipine (Calcium Channel Blocker):
- Amlodipine works by inhibiting the influx of calcium ions into the smooth muscle cells of the blood vessels and heart. This leads to relaxation and dilation of the arteries, resulting in lower blood pressure.
Pharmacokinetics:
- Telmisartan and amlodipine are both absorbed well after oral administration. They are metabolized in the liver and excreted in the feces and urine. The combination tablet allows for convenient once-daily dosing.
Telmisartan & Amlodipine Tablets – Side-effects
Common Side Effects:
- Dizziness or lightheadedness
- Swelling of ankles, feet, or legs (peripheral edema)
- Headache
- Fatigue or weakness
Less Common Side Effects:
- Rapid or irregular heartbeat
- Increased levels of blood potassium
- Flushing or warmth in the face, neck, or chest
- Muscle cramps or weakness
