What is Sitagliptin Tablets ?
- Sitagliptin is an oral antidiabetic medication that belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. It is used in the treatment of type 2 diabetes to help manage blood sugar levels.
Sitagliptin Tablets Uses
- Type 2 Diabetes Management:
- Sitagliptin is prescribed to individuals with type 2 diabetes as part of their treatment plan.
- It is typically used in conjunction with a healthy diet and regular exercise to improve blood sugar control.
- Monotherapy or Combination Therapy:
- Sitagliptin can be used as a standalone medication (monotherapy) when diet and exercise alone do not provide adequate control of blood sugar levels.
- It is also frequently used in combination with other antidiabetic medications to enhance blood sugar management.
- Adjunct to Diet and Exercise:
- Sitagliptin, when used alongside a proper diet and regular physical activity, helps lower elevated blood sugar levels and improves glycemic control.
- Long-term Glycemic Control:
- Sitagliptin can assist in achieving long-term glycemic control in individuals with type 2 diabetes, helping to reduce the risk of diabetes-related complications.
Sitagliptin Tablets – Mechanism of Action and Pharmacology
- Inhibition of Dipeptidyl Peptidase-4 (DPP-4):
- Sitagliptin works by inhibiting the action of the DPP-4 enzyme, which is responsible for breaking down incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP).
- Increased Incretin Hormone Levels:
- By inhibiting DPP-4, sitagliptin increases the levels of GLP-1 and GIP, which enhance the release of insulin from the pancreas in response to meals. This results in better blood sugar control.
Sitagliptin Tablets – Side-effects
- Nausea or vomiting
- Diarrhea
- Stomach upset or abdominal pain
- Upper respiratory tract infection
- Headache
- Hypoglycemia (low blood sugar levels) when used in combination with other antidiabetic medications
- Joint pain
