Levosulpiride Tablets

What is Levosulpiride Tablets Tablet ?

Levosulpiride is a drug that belongs to a class of medications known as prokinetic agents. It is primarily used to treat gastrointestinal disorders by improving gastrointestinal motility, which means it helps in moving food through the digestive system.

Levosulpiride Tablets Tablet Uses

• Functional Dyspepsia: This is a condition characterized by recurrent pain or discomfort centered in the upper abdomen. It is often associated with bloating, early satiety (feeling full after eating only a small amount), and nausea.
• Gastroesophageal Reflux Disease (GERD): Levosulpiride may be prescribed as part of the treatment for GERD, a condition where stomach acid frequently flows back into the esophagus, causing symptoms like heartburn and acid regurgitation.
• Irritable Bowel Syndrome (IBS): Levosulpiride can be used to manage symptoms of IBS, which can include abdominal pain, bloating, diarrhea, and constipation.
• Nausea and Vomiting: It can be used to alleviate symptoms of nausea and vomiting, especially in cases where these symptoms are related to gastrointestinal disorders.
• Postoperative Gastroparesis: Gastroparesis is a condition where the stomach takes longer than normal to empty its contents. This can occur after surgery, and Levosulpiride may be used to help restore normal gastric motility.
• Other Gastrointestinal Disorders: In some cases, Levosulpiride may be prescribed for other gastrointestinal disorders where impaired motility is a significant issue.

Levosulpiride Tablet – Mechanism of Action and Pharmacology

• Dopamine Receptor Antagonism: Levosulpiride primarily works by blocking dopamine receptors in the brain and gastrointestinal tract. It has a higher affinity for a specific subtype of dopamine receptor called D2 receptors. By inhibiting these receptors, levosulpiride enhances the release of acetylcholine, a neurotransmitter that stimulates the movement of the digestive tract.
• Stimulation of Motility: By inhibiting the inhibitory effects of dopamine on gut motility, levosulpiride increases the release of acetylcholine in the gut. Acetylcholine is a neurotransmitter that stimulates smooth muscle contractions in the digestive tract, promoting the movement of food.
• Reducing Gastric Emptying Time: Levosulpiride helps to decrease the time it takes for food to pass through the stomach and enter the small intestine. This effect can be beneficial in conditions where delayed gastric emptying is a problem.

Levosulpiride Tablets – Side-effects

• Gastrointestinal Disturbances:
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
• Central Nervous System Effects:
  • Drowsiness or sedation
  • Headache
  • Dizziness
  • Restlessness