What is Glibenclamide Tablets ?
Glibenclamide, also known as glyburide in the United States, is a medication used in the treatment of type 2 diabetes. It belongs to a class of drugs called sulfonylureas.
Glibenclamide Tablets Uses
- Lowering Blood Sugar Levels: Glibenclamide helps to lower high blood sugar levels by stimulating the pancreas to release more insulin. Insulin is a hormone that facilitates the uptake and utilization of glucose (sugar) by cells, which in turn reduces blood sugar levels.
- Type 2 Diabetes Management: Glibenclamide is prescribed for individuals with type 2 diabetes whose blood sugar levels are not adequately controlled through lifestyle modifications like diet and exercise alone.
- Adjunct to Diet and Exercise: It is typically used as an adjunct (supplementary) treatment to a balanced diet and regular exercise routine.
Glibenclamide Tablets – Mechanism of Action and Pharmacology
Mechanism of Action:
- Stimulation of Insulin Release: Glibenclamide primarily acts on the beta cells of the pancreas. It binds to specific receptors on the surface of these cells, known as sulfonylurea receptors. This binding leads to a series of events that ultimately result in an increased release of insulin.
- Closure of ATP-Sensitive Potassium Channels: Inside the beta cells of the pancreas, there are ATP-sensitive potassium channels. These channels play a role in regulating insulin release. Glibenclamide inhibits these channels
Glibenclamide Tablets – Side-effects
- Weight Gain: Some people may experience weight gain while taking glibenclamide.
- Gastrointestinal Upset: This can include nausea, stomach pain, and diarrhea. These symptoms are usually temporary.
- Skin Reactions: In rare cases, glibenclamide can cause skin rashes or itching. If you experience any skin reactions
