What is Glibenclamide & Metformin Tablets ?
Glibenclamide and Metformin Tablets are a combination medication used to treat type 2 diabetes. Let me explain each component individually:
- Glibenclamide (also known as Glyburide in the United States): This is an oral anti-diabetic drug that belongs to a class of medications called sulfonylureas. It works by stimulating the pancreas to release more insulin and by helping the cells in your body use insulin more effectively. This helps lower blood sugar levels.
- Metformin: It is another oral anti-diabetic medication that belongs to the class of drugs known as biguanides. Metformin works by decreasing the amount of sugar produced by the liver and increasing the sensitivity of muscle cells to insulin,
Glibenclamide & Metformin Tablets Use
These tablets are typically prescribed for people with type 2 diabetes who have not been able to adequately manage their blood sugar levels through lifestyle changes alone. They are used to lower blood sugar levels and improve overall glycemic control.
Glibenclamide & Metformin Tablets – Mechanism of Action and Pharmacology
Glibenclamide (Glyburide):
Mechanism of Action:
- Glibenclamide belongs to a class of medications called sulfonylureas.
- It acts by binding to specific receptors on the surface of pancreatic beta cells. This binding triggers a series of events that ultimately lead to an increase in the release of insulin.
Metformin:
Mechanism of Action:
- Metformin belongs to the biguanide class of medications.
- It primarily works by reducing the amount of sugar produced by the liver. It does this by decreasing the liver’s production of glucose and increasing the sensitivity of muscle cells to insulin.
Glibenclamide & Metformin Tablets – Side-effects
- Weight Gain: Some people may experience weight gain while taking glibenclamide.
- Gastrointestinal Upset: This can include nausea, stomach pain, and diarrhea.
- Skin Reactions: In rare cases, glibenclamide can cause skin rashes or itching.
