What is Fluticasone Propionate Cream ?
Fluticasone propionate cream is a topical medication that contains the active ingredient fluticasone propionate. Fluticasone propionate is a synthetic corticosteroid, which means it is a man-made version of a naturally occurring hormone in the body called cortisol.
When used in cream form, fluticasone propionate is typically applied to the skin to help reduce inflammation, itching, and redness associated with various skin conditions, such as eczema, psoriasis, and allergic reactions. It works by inhibiting the release of certain substances in the body that cause inflammation.
Fluticasone Propionate Cream Use
- Clean and Dry the Affected Area: Before applying the cream, wash the affected area with mild soap and water, and pat it dry gently.
- Apply a Thin Layer: Take a small amount of the cream and apply a thin layer to the affected area. You should only use enough to cover the area without it being too thick.
- Gently Massage In: Use your fingertips to gently rub the cream into the skin until it is absorbed.
- Wash Hands After Application: It’s a good practice to wash your hands after applying the cream to avoid getting it on other parts of your body or transferring it to others.
- Frequency of Use: Follow the specific instructions provided by your healthcare provider or as indicated on the prescription label. In most cases, fluticasone propionate cream is applied once or twice daily, but this can vary depending on the condition being treated.
- Avoid Eyes, Nose, and Mouth: Be careful to avoid getting the cream in your eyes, nose, or mouth. If accidental contact occurs, rinse thoroughly with water.
- Do Not Cover with Bandages: In most cases, it’s not necessary to cover the treated area with bandages or dressings unless directed by your healthcare provider.
- Do Not Use on Broken or Infected Skin: Avoid applying fluticasone propionate cream to open wounds, cuts, or areas with active infections, as it may exacerbate the condition.
Fluticasone Propionate Cream – Mechanism of Action and Pharmacology
Mechanism of Action:
- Anti-Inflammatory Properties: Fluticasone propionate works by inhibiting the production and release of inflammatory mediators in the body. These mediators, such as prostaglandins and leukotrienes, are substances that play a role in the inflammatory response.
- Immunosuppressive Effects: It suppresses the activity of certain immune cells involved in the inflammatory process. This helps to reduce inflammation and relieve symptoms associated with various skin conditions.
- Decreased Immune Response: Fluticasone propionate can also suppress the immune system’s response, which is particularly useful in treating conditions where an overactive immune system contributes to inflammation, such as autoimmune skin disorders.
Pharmacology:
- Absorption: When applied topically in cream form, fluticasone propionate is absorbed through the skin. However, only a small amount of the drug is typically absorbed into the bloodstream. This helps to minimize systemic effects.
- Metabolism: Once absorbed, fluticasone propionate undergoes metabolism in the liver. It is converted into inactive metabolites that are eventually excreted from the body.
- Duration of Action: The effects of fluticasone propionate cream are generally localized to the site of application. This means that most of its action occurs in the skin and underlying tissues, and it has limited systemic effects.
- Half-Life: The half-life of fluticasone propionate, when applied topically, is relatively short,
Fluticasone Propionate Cream – Side-effects
- Skin Irritation: Some individuals may experience mild irritation at the application site. This can include redness, burning, itching, or dryness.
- Thinning of the Skin: Prolonged use of topical corticosteroids can lead to thinning of the skin, especially in areas where the skin is naturally thinner (like the face and genitals).
- Skin Discoloration: In some cases, the skin may become lighter or darker in color at the application site.
- Acne or Folliculitis: Some individuals may develop acne or folliculitis (inflammation of hair follicles) at the application site.
