What is Dacarbazine Injection ?
Dacarbazine is a chemotherapy medication available in injectable form. It is used in the treatment of various types of cancer, particularly malignant melanoma (a type of skin cancer) and Hodgkin’s lymphoma.
Dacarbazine Injection Uses
- Malignant Melanoma: Dacarbazine is primarily used in the treatment of malignant melanoma, a type of skin cancer.
- Hodgkin’s Lymphoma: It is also used in the treatment of Hodgkin’s lymphoma, a type of cancer that affects the lymphatic system.
- Soft Tissue Sarcoma: In certain cases, dacarbazine may be used in the treatment of soft tissue sarcomas.
Dacarbazine Injection – Mechanism of Action and Pharmacology
Dacarbazine is an alkylating agent that interferes with the DNA in cancer cells, preventing them from dividing and growing. It forms covalent bonds with DNA molecules, leading to DNA strand breaks and inhibition of DNA synthesis. This disruption of DNA structure ultimately inhibits the growth and reproduction of cancer cells.
Dacarbazine Injection – Side-effects
- Liver Function Changes: Dacarbazine can affect liver function, leading to changes in liver enzyme levels.
- Low Appetite: A decrease in appetite and weight loss may occur.
- Hair Loss: Dacarbazine can cause hair loss.
