What is Divalproex Sodium Tablets?
Divalproex sodium is a medication that is commonly used to treat certain neurological and psychiatric conditions. It is available in tablet form and is sometimes prescribed under brand names like Depakote and Depakote ER (extended-release). The active ingredient in divalproex sodium is valproic acid.
The medication works by affecting certain neurotransmitters in the brain and by regulating electrical activity in the nervous system. It can help prevent abnormal electrical discharges in the brain, which can trigger seizures, and stabilize mood in individuals with bipolar disorder.
Divalproex Sodium Tablets Use
- Epilepsy: Divalproex sodium is used to manage and prevent various types of seizures in individuals with epilepsy. The specific dosage and frequency of administration will depend on the type of seizures and the patient’s individual needs. It is essential to take the medication consistently as prescribed to maintain seizure control.
- Bipolar Disorder: Divalproex sodium is often prescribed as a mood stabilizer for people with bipolar disorder. It helps to manage the mood swings associated with this condition, including manic episodes and depressive episodes. The dosage and duration of treatment may vary depending on the phase of the disorder and the patient’s response to the medication.
Divalproex Sodium Tablets – Mechanism of Action and Pharmacology
- Enhancement of GABA Activity: Divalproex sodium increases the concentration of gamma-aminobutyric acid (GABA), a neurotransmitter that has inhibitory effects in the central nervous system. GABA helps to calm and stabilize nerve activity, reducing the likelihood of abnormal and excessive neuronal firing. By enhancing GABA activity, divalproex sodium can help prevent seizures and stabilize mood in individuals with bipolar disorder.
- Sodium Channel Inhibition: Divalproex sodium can inhibit voltage-gated sodium channels in the brain. These channels play a crucial role in the propagation of action potentials (electrical signals) in neurons. By reducing sodium influx into neurons, divalproex sodium helps regulate excessive electrical activity, which is particularly relevant in the context of epilepsy, where abnormal electrical discharges can lead to seizures.
- Calcium Channel Inhibition: Divalproex sodium also affects voltage-gated calcium channels. Inhibition of calcium channels can reduce neurotransmitter release, which can further contribute to the medication’s antiepileptic and mood-stabilizing effects.
Divalproex Sodium Tablets – Side-effects
- Gastrointestinal Effects:
- Nausea
- Vomiting
- Diarrhea
- Indigestion
- Abdominal pain
- Weight Gain: Some people may experience weight gain while taking divalproex sodium, which can be a concern for those with bipolar disorder.
