What is Calcium Do500 mgbesilate Capsules?
Calcium dobesilate is a medication used to treat various vascular disorders, particularly those related to blood vessel health. It belongs to a class of drugs known as venoactive agents, which means it affects the function of veins.
Calcium Dobesilate Capsules Use
- Chronic Venous Insufficiency (CVI): This is a condition where the veins in the legs have difficulty in returning blood to the heart. Symptoms may include swelling, pain, and varicose veins. Calcium dobesilate helps by strengthening the walls of blood vessels, improving blood flow, and reducing inflammation.
- Hemorrhoids: Calcium dobesilate may be used to manage symptoms associated with hemorrhoids. It can help reduce pain, bleeding, and inflammation.
- Diabetic Retinopathy: This is a complication of diabetes where high blood sugar levels damage the blood vessels in the retina. Calcium dobesilate may be used in conjunction with other treatments to help stabilize and protect the blood vessels in the eyes.
- Diabetic Macular Edema (DME): DME is another condition related to diabetes, where fluid accumulates in the macula, a part of the retina. Calcium dobesilate can help reduce the leakage of fluid from blood vessels in the retina.
- Varicose Veins: Calcium dobesilate can be used to manage symptoms of varicose veins, which are swollen and twisted veins often found in the legs.
- Post-Surgical Recovery: In some cases, calcium dobesilate may be prescribed to aid in the recovery of patients after certain types of surgery, particularly those involving blood vessel-related procedures.
Calcium Dobesilate Capsules – Mechanism of Action and Pharmacology
Mechanism of Action:
- Endothelial Protection: Calcium dobesilate has been shown to protect the endothelial cells that line blood vessels. It does this by preventing damage to these cells and helping to maintain their integrity.
- Anti-Inflammatory Effects: It has anti-inflammatory properties, which are thought to be partly responsible for its beneficial effects in conditions like chronic venous insufficiency. It helps to reduce inflammation in the blood vessel walls.
- Antioxidant Properties: Calcium dobesilate acts as an antioxidant, meaning it helps to neutralize harmful molecules called free radicals. Free radicals can cause damage to cells and contribute to various diseases, including those affecting blood vessels.
- Rheological Effects: This drug can influence blood flow characteristics, making blood less sticky or viscous. This can improve blood flow through smaller vessels.
Calcium Dobesilate Capsules – Side-effects
- Gastrointestinal upset, including nausea, vomiting, and diarrhea.
- Mild allergic reactions, such as skin rash or itching.
Uncommon side effects (may affect up to 1 in 100 people):
- Dizziness or lightheadedness.
- Headache.
- Flushing (redness and warmth of the skin).
- Feeling of weakness.
