What is Glibenclamide Tablets ?
- Glibenclamide, also known as glyburide in some regions, is an oral antidiabetic medication. It belongs to the class of drugs known as sulfonylureas. Glibenclamide is primarily used to treat individuals with type 2 diabetes, a condition where the body doesn’t produce enough insulin or the insulin produced does not work effectively.
Glibenclamide Tablets Uses
- Type 2 Diabetes Management:
- Glibenclamide tablets are primarily used to manage high blood sugar levels in people with type 2 diabetes.
- It helps control blood glucose levels and prevent complications associated with uncontrolled diabetes.
Glibenclamide Tablets – Mechanism of Action and Pharmacology
- Stimulating Insulin Release:
- Glibenclamide works by binding to specific receptors on the beta cells of the pancreas, stimulating them to release more insulin.
- Insulin is a hormone that helps in the uptake and utilization of glucose by cells, reducing blood sugar levels.
- Blocking Potassium Channels:
- Glibenclamide also blocks ATP-sensitive potassium channels in the beta cells of the pancreas. This blockade leads to calcium influx and subsequent insulin release.
Glibenclamide Tablets – Side-effects
- Hypoglycemia (Low Blood Sugar):
- Glibenclamide can cause low blood sugar levels (hypoglycemia). Symptoms may include shakiness, dizziness, sweating, confusion, and, in severe cases, loss of consciousness.
- Gastrointestinal Issues:
- Nausea, vomiting, diarrhea, and stomach upset are common gastrointestinal side effects.
- Skin Reactions:
- Skin reactions such as rash or itching may occur in some individuals.
- Weight Gain:
- Glibenclamide may cause weight gain in some people.
- Allergic Reactions:
- Allergic reactions to glibenclamide are rare but can include symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing.
- Liver Issues:
- Glibenclamide can affect liver function in rare cases, leading to symptoms like yellowing of the skin/eyes, dark urine, or persistent nausea/vomiting.
