What is Glimepiride Tablets ?
Glimepiride is a medication used to help lower blood sugar levels in individuals with type 2 diabetes. It belongs to a class of drugs known as sulfonylureas, which work by stimulating the release of insulin from the pancreas.
Glimepiride Tablets Use
Type 2 Diabetes: Glimepiride is indicated for the treatment of type 2 diabetes mellitus. This is a condition characterized by insulin resistance and impaired insulin secretion.
Post-Meal Blood Sugar Control: Glimepiride, like other sulfonylureas, is particularly effective at controlling blood sugar levels after meals (postprandial glucose)
Stimulates Insulin Release: The primary mechanism of action of Glimepiride is to stimulate the beta cells in the pancreas to release insulin.
Glimepiride Tablets – Mechanism of Action and Pharmacology
- Stimulation of Insulin Release: Glimepiride primarily works by stimulating the release of insulin from the beta cells of the pancreas. It does this by binding to specific receptors on the surface of these cells.
- Closure of Potassium Channels: When Glimepiride binds to the receptors on the beta cells, it causes the closure of ATP-sensitive potassium channels. This leads to a depolarization of the cell membrane.
- Calcium Influx: The depolarization of the cell membrane triggers the opening of voltage-gated calcium channels. This allows calcium ions to enter the beta cell.
Glimepiride Tablets – Side-effects
- Weight Gain: Some individuals may experience weight gain while taking Glimepiride. This can be due to increased insulin levels.
- Digestive Issues: This may include nausea, diarrhea, or constipation.
- Headache: Some people may experience headaches while taking Glimepiride.
