What is Glibenclamide & Metformin Tablets ?
- Glibenclamide:
- Glibenclamide, also known as glyburide in some regions, is an oral antidiabetic medication that belongs to a class of drugs known as sulfonylureas. It works by stimulating the pancreas to produce more insulin, which helps lower blood sugar levels. Insulin is a hormone that facilitates the uptake and utilization of glucose by cells.
- Metformin:
- Metformin is another oral antidiabetic medication, belonging to the biguanide class. It primarily works by reducing the amount of glucose produced by the liver and improving the sensitivity of muscle cells to insulin, allowing better utilization of glucose by the body.
Glibenclamide & Metformin Tablets Uses
- Type 2 Diabetes Management:
- Glibenclamide and Metformin Tablets are prescribed to individuals diagnosed with type 2 diabetes to help control their blood sugar levels.
- Blood Glucose Regulation:
- The combination of glibenclamide and metformin helps regulate blood glucose levels by stimulating insulin production and improving insulin sensitivity in the body.
- Enhanced Insulin Action:
- Glibenclamide encourages the pancreas to produce more insulin, while metformin improves the effectiveness of insulin, aiding in the uptake and utilization of glucose by cells.
- Reduction of Glucose Production:
- Metformin helps decrease the amount of glucose produced by the liver, a key factor in managing elevated blood sugar levels.
- Complementary Action:
- The combination of glibenclamide and metformin utilizes their complementary mechanisms of action to achieve better blood sugar control than using either medication alone.
Glibenclamide & Metformin Tablets – Mechanism of Action and Pharmacology
- Glibenclamide works by binding to specific receptors on the beta cells in the pancreas, stimulating them to release more insulin. Insulin then helps to lower blood sugar levels by facilitating the uptake of glucose into cells.
- Metformin primarily works by decreasing the amount of glucose produced by the liver and increasing the sensitivity of muscle cells to insulin. It also improves the uptake and utilization of glucose by cells.
Glibenclamide & Metformin Tablets – Side-effects
- Nausea or vomiting
- Diarrhea
- Stomach upset or abdominal pain
- Loss of appetite
- Hypoglycemia (low blood sugar levels) if the medication lowers blood sugar too much
- Headache
- Dizziness
- Rash or skin reactions
