What is Pregabalin Tablets?
Pregabalin works by reducing the abnormal electrical activity in the brain and nervous system. It is typically taken in the form of oral tablets or capsules. The dosage and duration of treatment will vary depending on the specific condition being treated and the individual’s response to the medication. It’s essential to take pregabalin exactly as prescribed by a healthcare professional, as misuse or abrupt discontinuation can lead to withdrawal symptoms and other potential side effects.
Pregabalin Tablets Use
- Neuropathic Pain: Pregabalin is often prescribed to manage chronic neuropathic pain, which is pain that results from damage or dysfunction in the nervous system. Common conditions that cause neuropathic pain include diabetic neuropathy, post-herpetic neuralgia (pain following a shingles outbreak), and neuropathic pain associated with conditions like fibromyalgia.
- Epilepsy: Pregabalin may be used as an adjunctive treatment for individuals with epilepsy, specifically in the management of partial-onset seizures.
- Generalized Anxiety Disorder (GAD): In some countries, pregabalin is approved for the treatment of generalized anxiety disorder.
Pregabalin Tablets – Mechanism of Action and Pharmacology
Mechanism of Action:
- Binding to Alpha-2 Delta Subunits: Pregabalin’s primary mechanism of action involves its binding to alpha-2 delta subunits of voltage-gated calcium channels in the central nervous system. This binding reduces the influx of calcium ions into neurons, leading to decreased neurotransmitter release, especially the release of excitatory neurotransmitters such as glutamate. By modulating calcium channel function, pregabalin decreases the excitability of nerve cells.
- Stabilizing Neuronal Excitability: Pregabalin’s ability to reduce neuronal excitability contributes to its anticonvulsant properties. By limiting the release of excitatory neurotransmitters and dampening the spread of abnormal electrical signals in the brain, it helps in preventing or reducing seizure activity.
Pharmacology:
- Absorption: Pregabalin is well absorbed when taken orally. It reaches peak plasma concentrations within about 1 to 1.5 hours after ingestion.
- Distribution: Pregabalin is widely distributed throughout the body, and it can cross the blood-brain barrier. Its volume of distribution is similar to total body water.
Pregabalin Tablets – Side-effects
- Dizziness
- Drowsiness
- Weight gain
- Peripheral edema
- Dry mouth
- Blurred vision
- Fatigue
