Glimepiride, Pioglitazone & Metformin HCL Tablets ?
- Glimepiride:
- Glimepiride is an oral antidiabetic medication that belongs to the sulfonylurea class. It works by stimulating the pancreas to produce more insulin, which helps lower blood sugar levels.
- Pioglitazone:
- Pioglitazone is an oral antidiabetic medication that belongs to the thiazolidinedione class. It primarily works by improving insulin sensitivity in muscle cells and reducing glucose production in the liver.
- Metformin Hydrochloride (HCL):
- Metformin is another oral antidiabetic medication, belonging to the biguanide class. It primarily works by reducing the amount of glucose produced by the liver and improving the sensitivity of muscle cells to insulin, allowing better utilization of glucose by the body.
Glimepiride, Pioglitazone & Metformin HCL Tablets Uses
- Type 2 Diabetes Management:
- This combination medication is used to manage high blood sugar levels in individuals with type 2 diabetes.
- It helps regulate blood glucose levels through various mechanisms: stimulating insulin production (glimepiride), improving insulin sensitivity (pioglitazone), and reducing glucose production (metformin).
Glimepiride, Pioglitazone & Metformin HCL Tablets – Mechanism of Action and Pharmacology
- Glimepiride:
- Stimulates the pancreas to release more insulin, aiding in lowering blood sugar levels by facilitating glucose uptake by cells.
- Pioglitazone:
- Enhances insulin sensitivity in muscle cells, improving glucose utilization and reducing glucose production in the liver.
- Metformin Hydrochloride (HCL):
- Reduces glucose production by the liver and improves sensitivity of muscle cells to insulin, aiding in glucose uptake and utilization.
Glimepiride, Pioglitazone & Metformin HCL Tablets – Side-effects
- Nausea or vomiting
- Diarrhea
- Stomach upset or abdominal pain
- Hypoglycemia (low blood sugar levels)
- Headache
- Dizziness
- Rash or skin reactions
- Weight gain
- Edema (swelling)
- Increased risk of fractures (especially with long-term pioglitazone use)